Methylcobalamin Vs Cyanocobalamin

Whether or not you want to take methylcobalamin or cyanocobalamin depends on a number of factors. For one thing, you have to consider the price and how the medicine is used in the body. You also have to think about its effects and how stable it is.


Among the many vitamin B12 supplements available, there are two main active forms: cyanocobalamin and methylcobalamin. While cyanocobalamin is inexpensive and effective, methylcobalamin is a much more efficient and bioavailable form of the nutrient.

Methylcobalamin is a natural co-enzyme. This form is not as stable as cyanocobalamin, but it does have an advantage when it comes to retaining the molecule in the body. This makes it a good choice for a variety of conditions. It also exhibits neuroprotective properties, helping to protect the brain and improve cognition.

Cyanocobalamin is a synthetic form. It has a cyanide molecule that attracts the cobalamin ion, which requires an energy-intensive process to convert to its bioactive form.

Methylcobalamin, on the other hand, is a direct-acting metabolite that bypasses the absorption cycle and thereby improves retention. It has a higher plasma protein binding capacity than its synthetic counterpart. In addition, it can act as a neuroprotective agent by indirectly increasing levels of Melatonin in the brain.

Methylcobalamin may also be more useful for people who suffer from chronic neurological conditions such as fibromyalgia, Parkinson’s disease, and Alzheimer’s disease. It may also be of benefit to those with homocysteine concentrations high enough to cause serious health problems.

While methylcobalamin is the most expensive and least efficient of the three forms of vitamin B12, it is still more cost-effective than cyanocobalamin. In fact, health industry insiders believe that methylcobalamin will soon dominate the supplement world.

In the end, you have to choose which is more beneficial to you. But if you’re looking for the best way to get your fix of this important nutrient, methylcobalamin is the answer. It is a great way to boost your b12 levels and is a good part of a comprehensive treatment protocol. But do your own research before you purchase a vitamin B12 supplement. You don’t want to make the mistake of buying the wrong one. You can test which is best for you with a free micronutrient test. This will help you see which of the two vitamin B12s is the most useful for you.


Getting your daily dose of vitamin B12 is essential to maintaining a healthy nervous system, immune function, energy, and mental health. The two main forms of vitamin B12 are cyanocobalamin and methylcobalamin. Each has their own advantages and disadvantages. While both are effective, methylcobalamin may be better for your body.

Typically, the recommended daily intake of methylcobalamin is between 1,000 and 1,500 ug. However, this amount is subject to individual preferences. Some adults opt for a smaller dose, while others take a higher dose.

When it comes to vitamin B12 supplements, cyanocobalamin has a higher concentration and stability. It is also cheaper and available in a wide variety of forms. A 2017 study in Integrated Medicine found that cyanocobalamin has too many risks to justify its use. The research concluded that if you are going to take a supplement, it is best to switch to the natural form.

Methylcobalamin is more stable and less toxic than cyanocobalamin. It is also better absorbed. In addition, methylcobalamin is less expensive. It is available in spray and cream forms.

When comparing methylcobalamin vs cyanocobalamin, it is important to remember that the cyanocobalance form is a synthetic, inorganic, and non-natural form. This means that the body has to undergo a conversion process. This can lead to digestive disorders and other side effects.

In contrast, methylcobalamin is a natural co-enzyme form, meaning that it is naturally occurring. The body uses it to convert homocysteine to methionine. This reduces the potential for damage to the heart, vascular system, and nerves. The cyanocobalance form also isn’t as light sensitive.

Both cyanocobalamin and methylcobalamin are available in supplements. In fact, a majority of generic vitamins contain either one. However, if you’re looking to buy a vitamin B12 supplement, it’s probably wise to purchase a methylcobalamin version.

Methylcobalamin also has a better retention rate than cyanocobalamin. It has a methyl group that acts as a receptor. This allows methylcobalamin to interact with the neurotransmitters in the brain differently. This may explain why methylcobalamin is more effective than cyanocobalamin.

As mentioned earlier, methylcobalamin is the most commonly used vitamin B12 supplement. It is the most effective, most reliable, and least expensive form.

Side effects

Whether or not you choose to use cyanocobalamin or methylcobalamin to boost your Vitamin B12 levels depends on your specific needs. But both are important to the health of the brain, nerves, and arteries.

Vitamin B12 is essential for energy production, cell growth, and the development of red blood cells. It also helps the body produce serotonin and is responsible for maintaining a positive mood. It is also necessary for the production of glutathione, the body’s primary antioxidant.

Methylcobalamin and cyanocobalamin are two different forms of Vitamin B12. Cyanocobalamin is a synthetic form of Vitamin B12, and it is a more stable product. It is also cheaper to produce. But cyanocobalamin is much more toxic than methylcobalamin.

Methylcobalamin is a naturally occurring form of Vitamin B12. It is found in animal-based foods. It is more effective, however, and is less toxic than cyanocobalamin. It is used to treat a deficiency of Vitamin B12. It can also be used to treat other conditions. It is sometimes used in diabetes and peripheral neuropathy.

Methylcobalamin works by breaking down the amino acid homocysteine to methionine. It is then converted into the super antioxidant glutathione. Methylcobalamin is better for your brain, vision, and nervous system than cyanocobalamin. It may also help you sleep better at night.

If you need to take a Vitamin B12 supplement, you should always check with your doctor. It is possible to develop an allergic reaction to cyanocobalamin, and if you are pregnant, you should avoid it.

Both forms of Vitamin B12 are safe to take, but some people might experience side effects from taking one or the other. Make sure to follow your doctor’s instructions and keep all medications out of the reach of children.

Cyanocobalamin should only be taken in rare cases when there is a vitamin B12 deficiency. It should be taken in an empty stomach, which means no food for at least two hours before your next meal. If you have a bowel disorder, you may have difficulty digesting it.

Methylcobalamin, on the other hand, is easier to absorb. It is also available in spray form.

Usage in the body

Among all the vitamin B12 forms, methylcobalamin is the one which is most easily absorbed. It is the form of the vitamin that is stored in the liver for about three to five years. Methylcobalamin also serves as the source of “CH3+”. This vitamin is important in the nervous system, as well as for the environment. It plays a role in the bio-methylation of certain heavy metals. It is also important for melatonin synthesis, as well as light sensitivity.

It is also known to support immune function. It protects RNA, DNA, and nerve and brain cells. It helps in the production of serotonin, which supports a positive mood. It also contributes to the formation of red blood cells. It also plays a role in the formation of a super antioxidant, glutathione. Its absorption rate is higher than that of cyanocobalamin. It is best absorbed on an empty stomach. It should not be taken in large amounts.

If you have a prescription for methylcobalamin, you must take it as directed by your doctor. You should also take the medication at the right time, as missed doses can cause harmful effects. When you take the medication, you should avoid direct contact with the air or heat. Methylcobalamin should be kept at a room temperature between 68°F and 77°F. You should not chew the tablet or swallow it whole. If you miss a dose, you should immediately take another one. You should also carry your medications in your bag or purse. It is also advisable to consult your doctor before taking any medicine.

It is possible to overdose on the drug, so it is important to follow the directions carefully. This can be a medical emergency. You should avoid using the drug if you are pregnant, breastfeeding, or under a doctor’s care. Methylcobalamin is considered safe by the Natural Medicines Database. It has little evidence of weight gain.

If you are taking Methylcobalamin, it is advisable to take it on an empty stomach. If you do not, you may experience less sleep and you might feel a bit tired the next morning.

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